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Experimental investigation of the yeast Hxk2/Snf1/Mig1 network.

Thèse de 60 mois

Détails de l’offre

Description du sujet :
PhD student in Molecular Biology at the Department of Chemistry and Molecular Biology, University of Gothenburg, Sweden
PROJECT: The research project “Experimental investigation of the yeast Hxk2/Snf1/Mig1 network” aims at a better understanding of the dynamic control mechanisms of the Hxk2/Snf1/Mig1 glucose signalling pathway employing single cell technology developed in the ISOLATE project. Here the available experimental platform based on fluorescence microscopy and microfluidic devices will be optimised, especially with regard to establishing cell arrays of synchronized cells as well as image analysis. Using in parallel Mig1 and Msn2 reporters, the control of cell-to-cell variability, thresholds and bistability mechanisms will be studied. The work will be performed in tight collaboration with physicists developing the experimental platform and theoreticians employing mathematical models.

Profil du candidat :
Requested Background and/or Interests:
Yeast biology, yeast genetics, glucose signalling, use of microfluidic devices, microscopy, image analysis, application of nano-sensor technology, ‘systems’ thinking. Preferably Master in relevant subject such as Molecular Biology; education in an additional relevant subject will be an advantage.
The applicant must be fluent in written and spoken English and must not have spent more time at an institute in Sweden than 12 months in the 3 years immediately prior to recruitment.
Application and selection procedures:
The positions are available in the group of Prof. Stefan Hohmann. The group studies signalling mechanisms in yeast using experimentation and modelling with focus on the HOG and other MAPK pathways as well as nutrient-induced signalling systems such as the Snf1 pathway.
Positions will be open until filled. The starting date should preferably be before July 1, 2012.
Support will be available with all formalities and issues when moving into Sweden. Sweden is part of the European Union.
The application should include (1) a max. one-page cover letter with a justification why this position was chosen as well as a career vision statement, (2) a complete CV with details on education, previous research activities and a list of publications (if any), (3) a copy of the passport or ID with picture, (4) two letters of recommendation.
Applications should be e-mailed, ideally as a single PDF, to stefan.hohmann@gu.se and maria.enge@gu.se. Applicants may be invited to a first interview via Skype and a second interview in Gothenburg.

Date limite de candidature : 15/06/12

Date de début du contrat : 02/07/12

Contact : Stefan HOHMANN (stefan.hohmann@gu.se)

Financement :

À négocier Financement public uniquement mensuel de 2000€ net.

SEVENTH FRAMEWORK PROGRAMME - THE PEOPLE PROGRAMME - Initial Training Networks (ITN). Recruitment of Early Stage Researchers (PhD students, maximum 4 years since graduation) from EC Member States and associated countries - also open to researchers from third countries. Researchers are required to move from one country to another when taking up the appointment. These positions are part of the Initial Training Project ISOLATE, aiming at developing different technologies for single cell analysis, with partner laboratories in Gothenburg, Groningen, Zürich, Oxford, Odense, Prague and Bremen PhD student positions in Sweden and at the University of Gothenburg are commonly for a period of five years including 60% of full time dedicated to research, 20% to scientific and professional education as well as 20% involvement as assistant in teaching. Students within the ISOLATE project are expected to attend scientific and professional development courses both locally as well as potentially at other partner universities and those courses and meetings organised by the project. It is further expected that students actively participate in meetings of the network and attend international scientific conferences. Students are also expected to spend certain periods in the laboratory of collaborating research groups within the project. The applicable salary follows the amounts allocated according to EC-funded ITN projects and the taxation regulations of Sweden and Gothenburg. The salary covers all social security and medical insurance and will be in the order of € 2,000 net (somewhat higher if family allowance applies) payable in Swedish Crowns.

Equipe/Service d'accueil

Molecular biology of yeast stress responses


Chef d'équipe : Stefan HOHMANN (stefan.hohmann@gu.se)

Domaine principal d'activité : Levures

Membres de l'équipe :

Laboratoire/Entreprise :

Department of Chemistry and Molecular Biology, Microbiology section

image e80a5784322076f5ccf0a4c5d3a1abb0f85c6a34.png


Directeur : Per SUNNERHAGEN

Laboratoire public (Code unité : University of Gothenburg)


Medicinaregatan 9C
University of Gothenburg, Box 462
41390 Gothenburg