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Translational Regulation and RNA localization in Saccharomyces cerevisiae

Post-Doc de 18 mois

Détails de l’offre

Description du sujet :
Offre de Post-Doc provenant du laboratoire de Joan Curcio aux US (Etat de New York).
Les données CONTACT sont donc : Joan Curcio, Wadsworth Center, ALBANY, New York, USA (et non JL Parrou , Toulouse). Les dates ne sont pas précisées dans l'annonce (1er septembre, date au hasard !), de même que le montant et la nature du financement.

" I am looking for a postdoc to work on Ty1 translational regulation and localization, in case you know of anyone looking. Here's the link to the job description. Thanks! Joan "
M. Joan Curcio, Ph.D.
Research Scientist, Wadsworth Center


The Ty1 retrotransposon is a model system for identifying conserved host:viral interactions involved in retrovirus and retrotransposon replication. We are characterizing cis-acting sequences and RNA: protein interactions that partition the trifunctional Ty1 mRNA between translation, packaging and reverse transcription. Ty1 mRNA is highly structured and regulatory sequences that govern its translation and localization overlap coding sequences. Using genome-wide screens, our lab has identified multiple host proteins required for the specialized translation of Ty1 RNA. The successful applicant will use in vivo and in vitro assays, ribosomal profiling, RNP purification and FISH/fluorescent microscopy to investigate the specialized translation and specific localization of Ty1 RNA.

The lab is in a modern interdisciplinary research building, the Center for Medical Sciences, within the Wadsworth Center, and is affiliated with the Hudson Valley RNA Club (hudsonvalleyrnaclub.org) and the University at Albany RNA Institute (www.albany.edu/rna). The Wadsworth Center Postdoc Association provides an array of career development opportunities. Albany is culturally diverse, affordable and close to cultural and recreational facilities and major metropolitan areas (New York, Boston and Montreal).

Profil du candidat :

Candidates should have a Ph.D. in Biochemistry, Molecular Biology or a related field and publications in peer-reviewed journals. Experience with in vitro and in vivo RNA structural and functional analyses, high throughput sequencing, fluorescent microscopy and/or yeast genetics is desirable.

A competitive, federally funded position (though Health Research, Inc.) is available for 18 months, and the position is renewable.


Applicants should send a CV, statement of research interests and career goals and 3 letters of reference to Joan Curcio curcio@wadsworth.org by August 1, 2012.

Joan Curcio, PhD
Wadsworth Center
Center for Medical Sciences
150 New Scotland Ave
PO Box 22002
Albany NY USA 12201-2002
E-mail: curcio@wadsworth.org

Date limite de candidature : 01/09/12

Date de début du contrat : 01/09/12

Contact : Jean-Luc PARROU (parrou@insa-toulouse.fr)

Equipe/Service d'accueil

Integrated Physiology and Functional Genomics of Yeast and Filamentous Fungi (PHYGE)


Chef d'équipe : Jean M FRANCOIS (fran_jm@insa-toulouse.fr)

Domaine principal d'activité : Levures & Champignons filamenteux

Membres de l'équipe :

Laboratoire/Entreprise :

Ingénierie des Systèmes Biologiques et des Procédés (LISBP)

image 4799ba4e32cce43e331d9cdf503db041f9eb6f5b.jpg


Directeur : Carole MOLINA-JOUVE

Laboratoire public (Code unité : UMR INSA - CNRS 5504 - INRA 792)


135 ave de Rangueil
31077 Toulouse Cedex04